Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Peptides, particularly bioactive peptides like collagen peptides, have a growing body of scientific evidence supporting their use in bone healing and repair. Collagen is a primary structural protein in bone, and hydrolyzed collagen peptides are believed to stimulate osteoblast (bone-forming cell) activity and enhance the synthesis of new bone matrix. Several animal studies and a limited number of human clinical trials have shown that collagen peptide supplementation may accelerate fracture healing, increase bone mineral density, and support bone strength, especially in populations at risk for osteoporosis or poor bone healing. However, most of the clinical evidence is modest in quality, often involving small sample sizes and short durations. For example, a 2018 randomized controlled trial suggested that collagen peptide supplementation improved bone mineral density in postmenopausal women, while preclinical studies have demonstrated enhanced fracture healing in rodents. Other peptides, such as parathyroid hormone (PTH) analogs like teriparatide, are used therapeutically for fracture healing, but these are pharmaceutical agents rather than dietary supplements. In summary, while there is scientific rationale and emerging evidence for the use of certain peptides in supporting bone healing, more large-scale, high-quality human studies are needed to firmly establish their efficacy for treating broken bones.

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