Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Leucine is an essential branched-chain amino acid known for its critical role in muscle protein synthesis. Its use in supporting bone healing, such as in cases of broken bones, is based on emerging but limited scientific evidence. Preclinical studies (mostly in animal models) suggest that leucine, by stimulating the mTOR pathway, may promote protein synthesis in osteoblasts (bone-forming cells) and enhance bone regeneration. Some research also indicates that leucine supplementation can help prevent muscle wasting and may indirectly support bone health by maintaining the muscle-bone unit during immobilization after fractures.

However, direct clinical evidence in humans for leucine’s effectiveness specifically in accelerating or improving fracture healing is still lacking. Most of the available data are extrapolated from studies on muscle recovery, sarcopenia, and general tissue repair. Some small-scale human studies and reviews suggest a potential benefit of combining leucine-rich protein or amino acid supplementation with rehabilitation in elderly or immobilized patients, but these findings are preliminary. Leucine is not a standard or standalone treatment for broken bones; calcium, vitamin D, and other factors are more central in bone repair protocols.

In conclusion, while there is a scientific rationale and some early evidence supporting leucine’s possible role in bone healing, robust clinical trials are needed. The evidence is currently weak (rated 2/5), and leucine should not be relied upon as a primary therapy for broken bones.

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