Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Human growth hormone (HGH) has scientific validation for its role in supporting bone healing and repair, though it is not routinely used clinically for this indication due to concerns about safety and regulatory approval. HGH stimulates the production of insulin-like growth factor 1 (IGF-1), which promotes osteoblast activity and bone matrix formation, both essential for bone regeneration. Several animal studies and some small human trials have demonstrated that administration of HGH can enhance the rate and quality of bone healing after fractures. For example, research in rats has shown that HGH accelerates fracture healing and increases bone callus formation. In limited clinical studies, HGH has been associated with increased bone turnover and in some cases, faster healing in patients with delayed union or nonunion fractures.

However, the overall quality and quantity of clinical evidence are limited. Most of the supporting data comes from preclinical (animal) research or small-scale human studies. There are concerns about potential adverse effects, including abnormal bone growth, metabolic disturbances, and the risk of malignancy with long-term use. As a result, while the mechanistic rationale and early evidence are promising, HGH is not widely accepted or approved as a standard treatment for broken bones. Further large, well-controlled clinical trials are necessary to establish definitive safety and efficacy for this use.

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