Evidence supporting the use of: Fibroblast growth factor
For the health condition: Broken Bones

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Fibroblast Growth Factor (FGF), particularly FGF-2 (basic FGF), has scientific evidence supporting its role in bone healing and regeneration. FGFs are a family of growth factors involved in cellular proliferation, differentiation, and tissue repair. In the context of bone healing, several preclinical and clinical studies have demonstrated that FGF-2 can stimulate the proliferation and differentiation of osteoblasts (bone-forming cells), enhance angiogenesis (formation of new blood vessels), and accelerate fracture repair.

Experimental studies in animal models have shown that local application of FGF-2 at fracture sites increases callus formation and bone strength. In humans, recombinant human FGF-2 (trafermin) has been used in some countries (such as Japan) to treat bone defects and non-union fractures. Clinical trials indicate that FGF-2 can improve bone regeneration, particularly in challenging cases like non-healing fractures, although it is not universally approved for this indication worldwide.

FGFs act by binding to specific receptors on cell surfaces, triggering signaling pathways that promote cellular activities essential for bone repair. While FGF-2 is not the standard of care everywhere, and its use is often in specialized or investigational settings, the scientific rationale and data supporting its efficacy are substantial. However, more large-scale, randomized controlled trials are needed to further establish its safety and optimal use in routine clinical practice.

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