Evidence supporting the use of: Epidermal Growth Factor
For the health condition: Broken Bones

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Epidermal Growth Factor (EGF) is a protein that plays a significant role in cell growth, proliferation, and differentiation. There is some scientific evidence supporting the use of EGF in bone healing, primarily from preclinical and early-stage studies. EGF is known to stimulate the proliferation of osteoblasts, the cells responsible for bone formation, and can enhance the expression of genes related to bone regeneration. In animal models, exogenous application of EGF has been shown to accelerate bone healing and increase bone formation at defect sites. For example, studies in rats and rabbits have demonstrated that EGF, when delivered locally to bone fractures, can improve healing outcomes compared to controls. However, the majority of evidence comes from laboratory and animal experiments, with limited human clinical data available. The use of EGF for bone healing in clinical practice is not yet established, and there is insufficient evidence from large-scale, well-controlled human trials to recommend its routine use for broken bone treatment. Some concerns remain about the optimal dose, delivery method, and potential side effects, such as excessive cell proliferation or tumorigenesis. In summary, while there is a scientific rationale and some early supporting evidence for EGF in bone repair, current evidence is still preliminary and does not fully validate its clinical use for broken bones. Clinical adoption would require more robust data from human studies.

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Products containing Epidermal Growth Factor

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