Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Cissus quadrangularis has a long history of traditional use for bone health, particularly in Ayurvedic and Siddha medicine, where it is called "Hadjod" or "bone setter." In recent decades, scientific interest has grown regarding its potential to support bone healing. Several animal studies have demonstrated that extracts of Cissus quadrangularis can accelerate the healing of bone fractures, likely by stimulating osteoblast proliferation, enhancing the deposition of bone matrix, and increasing mineralization. These effects are thought to be due to the plant’s content of phytoestrogens, vitamin C, and other bioactive compounds.

Human data is more limited but promising. A few small clinical trials have explored its use in fracture healing. For example, a randomized controlled trial published in the journal Ancient Science of Life (2008) reported faster healing times and improved pain scores in patients with mandibular fractures who received Cissus quadrangularis supplements compared to controls. Another study in Phytomedicine (2010) found improved fracture union and better functional outcomes in patients with long bone fractures.

Despite these encouraging findings, larger and more rigorous clinical trials are needed to confirm effectiveness and safety. The current scientific evidence, while promising and supportive of traditional claims, is not yet robust. Therefore, the use of Cissus quadrangularis for supporting bone healing is justified by both traditional practice and preliminary scientific studies, with a moderate level of scientific evidence (rated 3 out of 5).

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