Evidence supporting the use of: Five-leaf Chastetree
For the health condition: Breasts (swelling and tenderness)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 3

Five-leaf Chastetree (Vitex negundo) has a long history of use in traditional medicine systems such as Ayurveda, Unani, and traditional Chinese medicine. In these traditions, preparations of the plant—especially the leaves—are commonly applied topically or taken internally to address various gynecological complaints, including breast swelling and tenderness. The rationale for its use stems from its reputed anti-inflammatory, analgesic, and hormone-modulating properties, although the mechanisms were not fully understood historically.

Scientific studies on Five-leaf Chastetree (distinct from the closely related Vitex agnus-castus, or Chasteberry) are limited, particularly regarding its effects on breast conditions like mastalgia (breast pain) or premenstrual breast tenderness. However, traditional texts and ethnobotanical surveys document its use for these symptoms, often as poultices or decoctions. Some pharmacological studies have shown Vitex negundo extracts possess anti-inflammatory and analgesic activities in animal models, which could plausibly reduce breast swelling or discomfort.

However, there is a lack of high-quality clinical trials specifically evaluating the efficacy of Five-leaf Chastetree for breast swelling and tenderness in humans. Thus, while the traditional use is well-documented and partially supported by preclinical data, robust scientific validation is lacking, justifying a moderate evidence rating.

More about Five-leaf Chastetree
More about Breasts (swelling and tenderness)

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