Synopsis

Source of validity: Scientific
Rating (out of 5): 3

HMR lignan (7-hydroxymatairesinol), a phytoestrogen derived from the Norway spruce, is used primarily for its potential benefits in breast health due to its estrogen-modulating properties. Scientific research indicates that HMR lignan is converted in the human body to enterolactone, a compound in the lignan class of phytoestrogens. Several epidemiological and clinical studies have investigated the relationship between lignan intake and breast health, particularly focusing on hormone metabolism and breast cancer risk. While results are not uniformly conclusive, some studies suggest that higher dietary lignan intake is associated with a reduced risk of breast cancer, especially among postmenopausal women. The proposed mechanisms include modulation of estrogen receptor activity and influence on estrogen metabolism, which are relevant to breast tissue health. However, most of the evidence comes from studies on dietary lignans in general, rather than HMR lignan specifically, and much of the data is observational. Randomized controlled trials assessing direct effects of HMR lignan supplementation on breast health outcomes are limited. In summary, there is scientific interest and a moderate level of evidence supporting the use of HMR lignan for breast health, but more robust clinical trials are needed to establish definitive benefits.

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