Evidence supporting the use of: Diindolylymethane
For the body system: Breasts

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Diindolylmethane (DIM) is a compound formed during the digestion of indole-3-carbinol, which is found in cruciferous vegetables like broccoli and cabbage. Its relevance to breast health arises from its effects on estrogen metabolism. Several laboratory and animal studies have shown that DIM can modulate estrogen activity, favoring the production of less potent estrogen metabolites that are believed to be less likely to promote the development of hormone-dependent cancers, including breast cancer. Some small clinical studies have explored DIM supplementation in humans, showing changes in urinary estrogen metabolites that suggest a shift toward a potentially protective profile. However, robust clinical trials demonstrating a reduction in breast cancer risk or direct improvement in breast health in humans are lacking. Thus, while the scientific rationale exists and early evidence is promising, the overall quality and quantity of clinical evidence are still limited. DIM is not specifically a traditional remedy for breast health, and its use is primarily based on findings from modern biomedical research rather than historical or ethnobotanical practice.

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