Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Valerenic acid is a major active constituent of Valeriana officinalis (valerian root), a plant traditionally used for its sedative and anxiolytic properties. The "brain body system" refers primarily to neurological and psychological health, including sleep, mood, and cognitive function. Scientific studies have indicated that valerenic acid acts as a modulator of the gamma-aminobutyric acid (GABA) system in the brain, which is the primary inhibitory neurotransmitter system responsible for reducing neuronal excitability. Valerenic acid has been shown in vitro and in animal models to bind to GABA_A receptors, leading to sedative and anxiolytic effects. Several clinical trials on valerian root extracts (which contain valerenic acid) suggest modest efficacy in improving sleep quality and reducing symptoms of anxiety, although results are mixed and often limited by methodological weaknesses.

There is ongoing debate regarding the precise role of valerenic acid versus other constituents of valerian root, but its presence is generally considered important for the observed effects. While evidence exists for benefits to the brain body system, particularly in sleep and possibly anxiety, it is not definitive, and further well-controlled studies are needed. Overall, the scientific evidence supporting valerenic acid for brain-related health is moderate.

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