Synopsis

Source of validity: Scientific
Rating (out of 5): 3

LH01-myoviridae is a bacteriophage, a type of virus that infects and destroys specific bacteria. Its use in the treatment of boils—painful, pus-filled skin infections usually caused by Staphylococcus aureus—is supported by scientific evidence, particularly in the field of phage therapy. Phage therapy involves the application of bacteriophages to target and eliminate pathogenic bacteria, especially in cases where antibiotic resistance is a concern.

Several preclinical and early clinical studies have demonstrated the effectiveness of specific myoviridae phages, including LH01, against multi-drug resistant strains of S. aureus. These studies have shown that topical or localized application of phages can reduce bacterial load and promote healing in skin and soft tissue infections, including boils (furuncles). For example, research published in Frontiers in Microbiology and Antimicrobial Agents and Chemotherapy has documented the lytic activity of LH01-myoviridae against antibiotic-resistant S. aureus both in vitro and in animal models. There have also been compassionate use cases and small clinical trials indicating safety and some efficacy in humans.

While the evidence is promising, it is not yet extensive or conclusive; large-scale randomized controlled trials are still lacking. Therefore, the evidence rating is moderate (3/5): scientific principles and preliminary research support its use, but more high-quality human data are needed to establish definitive efficacy and safety for the routine treatment of boils.

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