Evidence supporting the use of: L-Alanyl-Glutamine
For the health condition: Body Building

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

L-Alanyl-Glutamine is a dipeptide composed of the amino acids L-alanine and L-glutamine. It is used in sports nutrition, particularly in bodybuilding, primarily for its potential to support muscle recovery and enhance hydration. The scientific rationale is that glutamine is a conditionally essential amino acid that may become depleted during intense exercise, potentially impairing immune function and muscle recovery. The dipeptide form (L-Alanyl-Glutamine) is more stable and better absorbed in the gut than free glutamine, making it attractive for supplementation.

Several clinical studies have investigated L-Alanyl-Glutamine supplementation in athletes. Evidence suggests that it can improve markers of hydration and electrolyte absorption during prolonged exercise, and may modestly reduce markers of muscle damage and promote recovery. However, the direct translation of these effects into significant improvements in muscle growth or strength in bodybuilders is less well-established. Most benefits are related to recovery and gut health rather than direct anabolic effects.

Overall, while there is scientific evidence supporting the use of L-Alanyl-Glutamine for improving recovery and hydration in active individuals, the evidence specifically supporting its use for muscle growth or direct bodybuilding outcomes is moderate (hence the rating of 3/5). More research is needed to clarify its direct effects on performance and muscle hypertrophy in resistance-trained athletes.

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