Evidence supporting the use of: Anti-aromatase
For the health condition: Body Building

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Anti-aromatase agents, also known as aromatase inhibitors (AIs), are scientifically validated for their use in bodybuilding, primarily as ancillary drugs during anabolic steroid cycles. Aromatase is the enzyme responsible for converting androgens (such as testosterone) into estrogens. When bodybuilders use anabolic steroids, especially those that are aromatizable (convertible to estrogen), there is a risk of elevated estrogen levels. This can lead to side effects such as gynecomastia (development of breast tissue in men), water retention, and increased fat deposition. Aromatase inhibitors like anastrozole, letrozole, and exemestane work by blocking this conversion, thereby reducing estrogen-related side effects.

Evidence supporting the use of AIs in this context comes from clinical studies in populations using exogenous testosterone, such as patients undergoing testosterone replacement therapy or male-to-female transgender individuals. These studies consistently show that AIs effectively reduce circulating estrogen levels and mitigate estrogenic side effects. However, while their efficacy in reducing estrogen is well-established, there are potential risks, including adverse effects on cholesterol levels, bone health, and mood. There is limited research specifically focused on healthy bodybuilders, but the pharmacological rationale and extrapolation from clinical populations support their use for estrogen management during steroid cycles. Thus, the justification for their use in bodybuilding is based on a solid scientific foundation, though with an understanding of associated risks and the need for careful monitoring.

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Products containing Anti-aromatase

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