Evidence supporting the use of: Alpha-Ketoglutarate
For the health condition: Body Building

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Synopsis

Source of validity: Scientific
Rating (out of 5): 1

Alpha-Ketoglutarate (AKG) is sometimes marketed to bodybuilders and athletes based on its role in the Krebs cycle (a central metabolic pathway) and amino acid metabolism. The theoretical basis for using AKG in bodybuilding is that it could help enhance energy production, support protein synthesis, and aid in recovery. Some supplement companies also claim it may help reduce muscle breakdown and promote muscle growth.

However, scientific evidence supporting these claims is extremely limited. A handful of small human studies have explored AKG supplementation, mainly in clinical populations (such as critically ill patients or those undergoing surgery) rather than healthy athletes. There is little data specifically examining its effect on muscle mass, strength, or performance in bodybuilders. A few early studies suggested possible benefits for nitrogen balance and muscle protein metabolism, but subsequent research has not convincingly replicated these effects in athletes or healthy individuals.

Overall, the use of AKG for bodybuilding is based more on a plausible biochemical rationale than robust clinical evidence. Current research does not support significant benefits for muscle growth, recovery, or performance in healthy adults. While AKG is not without biological activity, its effectiveness as a bodybuilding supplement remains unproven.

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Other ingredients used for Body Building

7-Keto-DHEA
Acetyl L-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
anchovies
ashwagandha
aspartic acid
beta-alanine
bovine
branched-chain amino acids
caffeine
capsaicinoids
Coleus forskohlii
conjugated linoleic acid (CLA)
creatine monohydrate
curcumin
gelatin
ginseng
greens blend (proprietary)
hydroxycitric acid
l-isoleucine
iron
L-cysteine
L-glutamine
L-glycine
L-leucine
L-methionine
L-ornithine
L-valine
magnesium
maltodextrin
Milk
omega-3 fatty acids
ornithine alpha-ketoglutarate
protein
Almond fruit
vitamin D
Whey protein
Zinc
wheat germ
Algae
chickpea protein
brown rice protein
AMP-activated protein kinase (AMPK)
1,3,7-Trimethylpurine-2,6-dione
4-DHEA
arginine alpha ketoglutarate
arachidonic acid
Arginine malate
Alpha glyceryl
Alpha-ketoisocaproic acid
Adenosine triphosphate (ATP)
Algal protein
Alpha hydroxyisocaproic acid
anti-aromatase
animal protein
Beef Protein
beef
Beef liver
bovine protein
beta-lactoglobulin
ba ji tian
banana
chia seed
casein
cardarine
Citrus
capsaicin
capsiate
D-Aspartic Acid
dihydrocapsiate
deer velvet
D-Ribose
dextrose
eurycomanone
egg
Eurycoma Longifolia
ecdysteroids
Ethyl-Alpha-Guanido-Methyl-Ethanoate
ecdysterone
Egg protein
fungus
Fadogia agrestis
forskolin
glucose
hydroxymethylbutyrate
HMB hydroxymethylbutyrate
Isoleucine
ketosterones
leucine alpha-ketoglutarate
lactalbumin
lactoglobulin
lipids
Marine protein
Milk Protein
Phytoecdysteroid
Protodioscin
Phosphatidic Acid
Palatinose
propionate ester
Peptides
Rhaponticum
Synephrine
Safed musli
Ursolic Acid
Yohimbine
Zucchini

Products containing Alpha-Ketoglutarate

We currently have no products on Caring Sunshine that contain this ingredient.