Evidence supporting the use of: Alpha-GPC
For the health condition: Body Building

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha-Glycerylphosphorylcholine (Alpha-GPC) is a cholinergic compound often used for its potential cognitive-enhancing properties. Its use in bodybuilding or athletic performance is based on some scientific evidence, though the quality and extent of this evidence remain limited. Several small human studies have explored Alpha-GPC’s impact on physical performance, particularly related to power output. For example, a 2015 double-blind, placebo-controlled study by Ziegenfuss et al. found that a single dose of 600 mg Alpha-GPC increased lower body force production in healthy young men. Another study indicated potential benefits for growth hormone secretion, which is sometimes cited as a mechanism for muscle growth, though these effects were modest and acute.

Despite these findings, the overall body of evidence is not robust. Most studies have small sample sizes, short durations, and focus on acute rather than chronic supplementation. There is a lack of large-scale, long-term trials confirming significant benefits for muscle hypertrophy, strength, or fat loss. Thus, while the scientific rationale for Alpha-GPC in bodybuilding exists—primarily through its potential to increase acetylcholine availability and possibly stimulate growth hormone—the evidence is preliminary. It is not a traditional remedy for bodybuilding, but its use is supported by emerging, albeit limited, scientific data.

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Products containing Alpha-GPC

We currently have no products on Caring Sunshine that contain this ingredient.