Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Adenosine 5'-triphosphate disodium (ATP) has been explored as a supplement for bodybuilders and athletes due to its central role in cellular energy metabolism. ATP is the primary energy currency of the cell, fueling muscle contractions during high-intensity, short-duration activities such as weightlifting. The rationale behind ATP supplementation is that increasing extracellular ATP might enhance muscular performance, delay fatigue, or improve recovery.

Some scientific studies have investigated oral ATP supplementation. A few small randomized controlled trials suggest that daily ATP supplementation (e.g., 400 mg/day) over several weeks may provide modest improvements in muscle strength, power output, and resistance to fatigue in trained individuals, especially when combined with resistance training. For example, a 2013 study in the Journal of the International Society of Sports Nutrition reported increased muscle mass and strength gains in resistance-trained men supplementing with ATP compared to placebo. However, other studies have found no significant benefits, and oral ATP's bioavailability remains questionable, as it is rapidly degraded in the gut.

Overall, while there is some preliminary scientific evidence supporting ATP supplementation for bodybuilding and athletic performance, the results are mixed, and the quality of evidence is moderate at best. Most authoritative bodies do not currently recommend ATP supplementation due to limited and inconsistent data. Further research is required to elucidate its efficacy, optimal dosing, and long-term safety.

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