Evidence supporting the use of: 19-NorAndrost-4ene-3b-ol,17-one
For the health condition: Body Building
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
19-NorAndrost-4ene-3b-ol,17-one (commonly known as 19-norandrostenol or norandrostenol) is a synthetic prohormone. It is structurally related to nandrolone, an anabolic-androgenic steroid. The use of 19-norandrostenol and similar prohormones in bodybuilding is primarily based on their ability to convert in vivo to active anabolic steroids, such as nandrolone, which may promote muscle growth and improve recovery. However, the direct scientific evidence for the efficacy and safety of this specific compound in humans is limited. Most of the available data stems from studies on nandrolone or related prohormones, not on 19-NorAndrost-4ene-3b-ol,17-one itself.
Some early research and anecdotal reports suggest that prohormones like this can mildly increase muscle mass and strength, but these effects are generally less pronounced than those of prescription anabolic steroids. Moreover, due to potential for conversion to active steroids, there are significant safety and legal concerns, and such compounds are banned by most athletic organizations. The overall quality of evidence is low, consisting mainly of in vitro data, animal studies, or small, poorly controlled human studies. Thus, while there is a mechanistic basis and some scientific rationale for its use in bodybuilding, robust clinical evidence is lacking, and the rating reflects this limited support.
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