Evidence supporting the use of: Immunoglobulins
For the health condition: Blood Poisoning

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Immunoglobulins for Blood Poisoning (Sepsis): Scientific Evidence

Immunoglobulins, specifically intravenous immunoglobulins (IVIG), have been investigated as an adjunctive therapy for blood poisoning, also known as sepsis. Sepsis is a severe, life-threatening response to infection that can lead to organ dysfunction and shock. The rationale for IVIG use is based on its ability to neutralize bacterial toxins, modulate the immune response, and provide passive immunity, especially when endogenous antibody production is inadequate.

Several clinical trials and meta-analyses have evaluated the efficacy of IVIG in sepsis. Some studies suggest a reduction in mortality, particularly with IgM-enriched preparations; however, the results are inconsistent. The most recent Cochrane reviews (2013, updated 2018) concluded that polyclonal IVIG might reduce mortality in adults with sepsis, but highlighted considerable heterogeneity and limitations in study quality. Guidelines such as those from the Surviving Sepsis Campaign do not recommend routine use of IVIG due to insufficient high-quality evidence, though they acknowledge potential benefit in specific cases or subgroups.

In summary, there is moderate scientific support for the use of immunoglobulins in sepsis, especially in selected patients or with certain preparations. However, the evidence is not robust enough for universal recommendation, and use is typically reserved for severe or refractory cases in clinical practice.

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