Evidence supporting the use of: Adsorbant
For the health condition: Blood Poisoning

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Adsorbents—such as activated charcoal, polymyxin B hemoperfusion columns, or other extracorporeal adsorbent devices—are used as adjunctive treatments in cases of blood poisoning (sepsis), particularly when associated with endotoxemia or certain drug toxicities. The scientific rationale is that adsorbents can bind and remove circulating toxins, bacterial endotoxins (lipopolysaccharides), inflammatory mediators, or specific drugs from the bloodstream, potentially reducing the severity of systemic inflammation and organ damage.

Evidence supporting their use is strongest for certain clinical scenarios. For example, hemoperfusion with polymyxin B columns has been studied extensively in sepsis caused by Gram-negative bacteria. Several clinical trials, including the large EUPHRATES trial, have examined outcomes in septic shock patients undergoing endotoxin adsorption. While some studies show hemodynamic improvement and reduced endotoxin levels, consistent mortality benefit has not been conclusively demonstrated, and guidelines vary in their recommendations.

For drug poisoning, activated charcoal hemoperfusion is well-established for specific toxins (e.g., theophylline, carbamazepine, phenobarbital), particularly when conventional treatments are insufficient. The use of oral activated charcoal in poisoning (not sepsis) is also evidence-based but does not apply to blood poisoning directly.

Thus, the use of adsorbents in blood poisoning has scientific support, especially as a rescue therapy in severe, refractory cases. However, routine use in all sepsis cases is not universally endorsed, and ongoing research aims to better define patient populations who will benefit most.

More about Adsorbant
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