Trichosanthis (commonly referring to the fruit or root of Trichosanthes kirilowii or related species) has been used in Traditional Chinese Medicine (TCM) for various purposes, including promoting the movement of blood and resolving "blood stasis." In TCM, "blood stasis" is a concept that broadly includes conditions where the circulation of blood is impaired, which can be interpreted as including blood clots or clot-related disorders according to modern perspectives.

Classical Chinese medical texts such as the Shennong Bencao Jing and subsequent compilations list Trichosanthis (often the fruit, known as "Gualou") as an ingredient in formulas intended to "open the chest," "transform phlegm," and "invigorate blood." Some formulas including Trichosanthis are traditionally used to address symptoms that might relate to angina or obstructed blood flow, which can be loosely associated with clot-related issues in modern understanding.

However, there is limited direct scientific research specifically supporting the use of Trichosanthis for prevention of blood clots. The evidence is mainly historical and based on TCM theory and clinical tradition rather than robust clinical trials or pharmacological studies demonstrating antithrombotic effects. As such, its use is justified primarily by tradition, with low to moderate support from historical use but lacking substantial modern scientific validation for this specific indication.