Evidence supporting the use of: Rutin
For the health condition: Blood Clots (prevention of)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Rutin is a flavonoid commonly found in certain fruits and vegetables, such as buckwheat, apples, and citrus. Scientific interest in rutin's effect on blood clot prevention arises from its ability to modulate pathways involved in coagulation and inflammation. Preclinical studies have shown that rutin can inhibit platelet aggregation and reduce the formation of blood clots (thrombi). Notably, a 2012 study published in the journal Journal of Clinical Investigation demonstrated that rutin inhibits protein disulfide isomerase (PDI), an enzyme essential for thrombus formation, in both mouse models and in vitro assays. These findings suggest that rutin has a biologically plausible mechanism for preventing abnormal clot formation without significantly increasing bleeding risk.

However, while animal and laboratory studies are promising, robust clinical trials in humans are limited. Most evidence currently comes from experimental models rather than large-scale human studies. There is some historical use of rutin in traditional medicine for strengthening blood vessels and addressing issues like hemorrhoids and varicose veins, but its routine use in humans specifically for blood clot prevention is not well established in clinical guidelines. Overall, rutin’s use for blood clot prevention is supported by moderate scientific evidence from preclinical research, but clinical validation is still needed to determine its effectiveness and safety for this purpose in humans.

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