Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Nattozimes is a proprietary blend of proteolytic enzymes, often derived from the fermentation of soybeans, and is designed to mimic the activity of nattokinase—the active enzyme in natto, a traditional Japanese food. The primary rationale for using Nattozimes in the prevention of blood clots is based on its fibrinolytic (clot-dissolving) activity, similar to nattokinase, which has been more extensively studied. Several in vitro and animal studies have demonstrated that nattokinase and related protease blends can enhance the breakdown of fibrin, the protein meshwork that constitutes blood clots. Some small human clinical trials have also suggested potential benefits in reducing clot formation or improving blood flow, though these are limited in size and quality.

Nattozimes itself, as a supplement, has less robust direct research compared to nattokinase; however, its inclusion in dietary supplements is based on the enzyme blend’s similarity in structure and function to nattokinase. The mechanism involves the direct degradation of fibrin and the promotion of endogenous fibrinolytic activity. Despite promising preliminary evidence, large-scale, high-quality human trials are lacking, and regulatory authorities have not formally approved Nattozimes for the prevention or treatment of blood clots. Individuals considering its use should consult healthcare professionals, especially since enzyme supplements may interact with blood-thinning medications.

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