Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Diosmin is a flavonoid commonly extracted from citrus fruits and is often used in combination with hesperidin for vascular conditions. Its primary clinical applications are for chronic venous insufficiency, hemorrhoids, and lymphedema. Regarding blood clot prevention (antithrombotic use), there is some scientific interest but limited robust evidence. Diosmin is thought to improve venous tone, reduce capillary permeability, and have anti-inflammatory effects, which may theoretically help reduce the risk factors associated with venous thrombosis. Some small clinical studies and animal research suggest diosmin can improve blood flow and reduce stasis in veins, potentially lowering thrombotic risk in patients with chronic venous disorders. However, there is little direct evidence from large-scale randomized controlled trials specifically demonstrating diosmin’s efficacy for preventing blood clots (deep vein thrombosis or pulmonary embolism) in the general population or in high-risk patients. Most guidelines do not recommend diosmin as primary or adjunctive therapy for blood clot prevention. Its use for this indication is thus supported by moderate scientific rationale and limited clinical data, but not by strong, direct evidence.

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