Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Danshen (Salvia miltiorrhiza) is a traditional Chinese medicinal herb that has been widely studied for its cardiovascular effects, including the prevention of blood clots. Scientific studies indicate that Danshen and its active compounds (such as tanshinones and salvianolic acids) exhibit antiplatelet, anticoagulant, and vasodilatory properties. These effects have been demonstrated in vitro, in animal models, and to a lesser extent in human clinical trials.

Mechanistically, Danshen inhibits platelet aggregation, reduces blood viscosity, and modulates the coagulation cascade. Some randomized controlled trials (RCTs) and meta-analyses suggest Danshen may reduce the risk of thrombosis and improve blood flow in conditions such as coronary heart disease and ischemic stroke. However, the quality of clinical evidence varies, with concerns about study design and sample sizes in many trials.

Despite these limitations, Danshen is included in official pharmacopeias (e.g., Chinese Pharmacopoeia) for cardiovascular indications and is commonly used in China as an adjunct for preventing and treating blood clots and related conditions. The evidence base is stronger than for many traditional remedies, but large, high-quality RCTs are still needed to definitively establish its efficacy and safety for this indication.

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