Evidence supporting the use of: Alpha-Linolenic Acid
For the health condition: Blood Clots (prevention of)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha-Linolenic Acid (ALA) is an omega-3 polyunsaturated fatty acid found in plant sources such as flaxseed, chia seeds, and walnuts. There is scientific interest in ALA for cardiovascular health, including its potential role in the prevention of blood clots (thrombosis). Several observational studies and some small clinical trials have investigated the antithrombotic effects of ALA, suggesting that higher dietary intake may be associated with reduced platelet aggregation and lower risk of clot formation. The proposed mechanisms include modulation of eicosanoid synthesis, reduction of inflammation, and improvement of endothelial function, all of which could theoretically decrease thrombosis risk.

However, the evidence supporting ALA’s efficacy in the prevention of blood clots is limited and less robust compared to long-chain marine-derived omega-3 fatty acids (EPA and DHA). Most clinical trials demonstrating significant antithrombotic effects have focused on EPA and DHA, with ALA showing weaker or inconsistent results. Systematic reviews and meta-analyses generally conclude that while ALA may have some cardiovascular benefits, definitive evidence for its use specifically in blood clot prevention is lacking. Thus, while there is some scientific rationale and preliminary data supporting ALA’s role, the evidence is not strong, and major clinical guidelines do not currently recommend ALA supplementation specifically for prevention of blood clots.

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