Vitamin E is commonly cited in traditional and popular home remedies for the treatment and support of blisters. The rationale behind its use largely stems from its well-known antioxidant properties and its role in skin health, particularly in wound healing and reducing scarring. Anecdotal reports suggest that applying vitamin E oil or capsules directly to blisters may promote faster healing and reduce discomfort. However, the scientific evidence specifically supporting vitamin E for blisters is limited. Most available studies on vitamin E and skin healing focus on its effects in other skin injuries, such as burns, surgical wounds, or scars, rather than blisters caused by friction or burns. Some small studies and case reports have suggested that topical vitamin E may help with epithelialization (skin regrowth), but results are mixed and not always positive. In some cases, topical vitamin E has even been associated with contact dermatitis or delayed wound healing. Overall, while vitamin E’s use for blisters is deeply rooted in traditional practice and supported by general knowledge of its role in skin health, there is little direct scientific evidence to validate its effectiveness for this specific condition. Medical guidelines do not typically recommend vitamin E for blister treatment, and care should be taken due to possible skin irritation in sensitive individuals.