Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Panthenol, also known as provitamin B5, is commonly used in topical formulations for its moisturizing and skin barrier-supporting properties. There is some scientific rationale for its use in supporting the healing of blisters, though high-quality, direct clinical trials specifically targeting blister treatment are limited. Panthenol is converted in the skin to pantothenic acid, a component of coenzyme A, which is essential for skin regeneration and repair. Studies demonstrate that panthenol can improve stratum corneum hydration, reduce transepidermal water loss, and promote the proliferation of fibroblasts, all of which support wound healing in general. Some clinical studies have shown that panthenol-containing creams and ointments accelerate healing in minor wounds, abrasions, and superficial burns, likely due to its anti-inflammatory and epithelialization-enhancing effects.

However, there is a lack of direct, robust evidence specifically evaluating panthenol's effectiveness in the treatment or healing of blisters. Its use in this context is supported by extrapolation from studies on minor wounds and irritations. It is commonly included in after-sun products and ointments for its soothing effect on compromised skin. In summary, while there is a scientific basis for using panthenol to support skin repair, and it is widely used for minor skin injuries, evidence directly supporting its use for blisters is limited and would be considered modest (evidence rating: 2 out of 5).

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