Evidence supporting the use of: Vitamin K
For the health condition: Bleeding (internal)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Vitamin K is scientifically validated for use in treating and preventing internal bleeding, particularly in cases involving vitamin K deficiency. Vitamin K is essential for the synthesis of clotting factors II, VII, IX, and X, which are necessary for blood coagulation. A deficiency in vitamin K impairs the body's ability to produce these clotting factors, which can result in bleeding diathesis, including spontaneous internal bleeding or excessive bleeding following injury or surgery. Clinical evidence supports the use of vitamin K (especially vitamin K1, or phytonadione) as the first-line therapy for reversing hypoprothrombinemia (low levels of prothrombin, a clotting factor) due to vitamin K deficiency. This condition can occur in newborns (hemorrhagic disease of the newborn) or in adults due to liver disease, malnutrition, or certain medications (such as warfarin, a vitamin K antagonist). Injectable or oral vitamin K rapidly restores the activity of clotting factors and helps control or prevent bleeding episodes. Numerous guidelines, including those from the World Health Organization and national hematology societies, recommend vitamin K administration in cases of active bleeding or elevated bleeding risk due to vitamin K deficiency. In summary, vitamin K’s role in the treatment and prevention of internal bleeding is strongly supported by both biochemical understanding and robust clinical trial and real-world evidence.

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