Stone Root (Collinsonia canadensis) has a long history of use in traditional herbal medicine, particularly among Native American and 19th-century eclectic practitioners. Traditionally, Stone Root was used to address various urinary tract disorders, including bladder infections (cystitis), urinary gravel, and other genitourinary complaints. The plant was believed to possess diuretic, astringent, and anti-inflammatory properties, which were thought to help soothe irritated urinary tissues and promote urine flow, potentially aiding the elimination of pathogens from the bladder.

Despite these traditional uses, there is a lack of modern clinical or preclinical scientific evidence specifically validating Stone Root’s effectiveness in treating bladder infections. The available literature consists mainly of anecdotal reports, historical texts, and herbalist accounts. No high-quality human trials, in vitro studies, or animal models have confirmed antimicrobial activity against common urinary pathogens or shown clear efficacy in resolving bladder infections. Thus, the rationale for its use remains rooted in tradition rather than evidence-based medicine.

In summary, while Stone Root has a traditional reputation for supporting urinary tract health and addressing bladder discomfort, its use for bladder infections is not substantiated by modern scientific research.