Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lactobacillus reuteri and Bladder Infection: Evidence Synopsis

Lactobacillus reuteri is a probiotic bacterium that has been studied for its potential role in preventing and managing urinary tract infections (UTIs), particularly in women. Scientific interest in this area stems from the observation that a healthy vaginal and urinary microbiome, dominated by Lactobacillus species, is associated with reduced risk of UTIs.

Several clinical studies and systematic reviews have examined whether probiotic supplementation with L. reuteri (often combined with other Lactobacillus strains, such as L. rhamnosus) can prevent recurrent bladder infections. The proposed mechanism involves restoring the natural microbial balance, thereby creating a hostile environment for uropathogens like Escherichia coli. L. reuteri can adhere to the urogenital mucosa, produce antimicrobial substances (e.g., reuterin), and modulate local immune responses.

Randomized controlled trials, including those published in reputable journals such as Clinical Infectious Diseases and The Journal of Urology, have shown that intravaginal or oral administration of L. reuteri may reduce the recurrence rate of UTIs in women, especially those prone to frequent infections. However, the magnitude of the effect is moderate, and results can be inconsistent depending on the probiotic formulation, dose, and patient population. Meta-analyses generally support a modest benefit, particularly as an adjunct to standard care or as an alternative to prophylactic antibiotics.

In summary, there is scientific evidence supporting the use of L. reuteri for prevention of recurrent bladder infections, but it is not definitive, and further large-scale studies are needed to clarify its clinical efficacy and optimal use.

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