Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Isothiocyanates are naturally occurring compounds found in cruciferous vegetables such as broccoli, cabbage, and watercress. The most well-studied isothiocyanate is sulforaphane. Scientific research has explored their potential role in supporting bladder health, primarily due to their chemoprotective properties. Several epidemiological studies have suggested an inverse relationship between the consumption of cruciferous vegetables and the risk of bladder cancer. For example, a study published in the International Journal of Cancer (2007) indicated that higher intake of isothiocyanate-rich vegetables was associated with a lower risk of bladder cancer. Mechanistically, isothiocyanates are known to induce phase II detoxification enzymes, such as glutathione S-transferases, in the bladder epithelium, enhancing the detoxification of potential carcinogens.

Animal studies have also demonstrated that isothiocyanates can inhibit the development of bladder tumors induced by chemical carcinogens. However, while the evidence supporting chemoprotection is moderate, direct evidence for isothiocyanates supporting general bladder health (such as reducing urinary tract infections or improving bladder function in non-cancer contexts) is limited. Most of the available evidence pertains to cancer prevention rather than general bladder support. Overall, their use is scientifically grounded, but the strength of evidence is moderate and primarily focused on cancer risk reduction rather than broader bladder health benefits.

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