Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Alpha phytosterol, more commonly referred to as beta-sitosterol (as "phytosterols" is a group of plant sterols with beta-sitosterol being the main component), has been investigated for its potential role in supporting or treating Benign Prostatic Hyperplasia (BPH). The use of phytosterols, especially beta-sitosterol, for BPH is primarily justified by scientific evidence rather than just tradition. Several randomized, placebo-controlled clinical trials and meta-analyses have evaluated their efficacy in improving urinary symptoms associated with BPH. A notable meta-analysis published in The Lancet (1995) and updated reviews have concluded that beta-sitosterol can improve urinary symptom scores and urinary flow measures in men with mild to moderate BPH compared to placebo. The mechanism of action is not fully elucidated but is thought to involve inhibition of 5-alpha-reductase and anti-inflammatory effects, though these are less potent than prescription drugs for BPH. However, the evidence is not as robust or extensive as for pharmaceutical agents like finasteride or tamsulosin. The studies are generally short-term (several months), and data on long-term efficacy and safety are limited. Thus, while there is moderate-quality scientific evidence supporting the use of phytosterols (specifically beta-sitosterol) for symptomatic relief in BPH, they are not considered a cure and are best viewed as an adjunct or alternative for mild cases.

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