Squawvine (Mitchella repens) has a long history of use in traditional herbal medicine, particularly by Native American and early European-American herbalists. It has been used to address a variety of women’s reproductive issues, as well as urinary tract concerns, including bedwetting (nocturnal enuresis) in children. Historical sources such as eclectic and Thomsonian herbal texts from the 19th and early 20th centuries mention squawvine as a "tonic" for the genitourinary system and sometimes as part of formulas intended to "strengthen" the bladder and pelvic floor muscles.

However, the evidence supporting its use for bedwetting is largely anecdotal and based on tradition rather than on clinical trials or pharmacological studies. Modern scientific research on squawvine is extremely limited, and there are no well-designed studies or clinical trials that validate its effectiveness for treating bedwetting. Its reputation in this area stems almost exclusively from herbal traditions and folk medicine rather than empirical data. As such, while it is sometimes cited in herbal compendia for this purpose, healthcare professionals generally do not recommend squawvine for bedwetting due to the lack of rigorous evidence.

In summary, squawvine’s use for bedwetting is justified primarily by tradition, with minimal supporting evidence from scientific research.