Evidence supporting the use of: Vitamin D3
For the health condition: Autoimmune Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin D3 (cholecalciferol) is increasingly used as an adjunct in the management of autoimmune disorders, backed by a growing body of scientific evidence. Vitamin D receptors are present on various immune cells, including T cells and dendritic cells, suggesting vitamin D’s immunomodulatory role. Research indicates that vitamin D3 influences both innate and adaptive immunity by modulating the activity and proliferation of immune cells, reducing the production of pro-inflammatory cytokines, and promoting the development of regulatory T cells, which help prevent autoimmune responses.

Multiple observational studies have reported lower serum vitamin D levels in patients with autoimmune diseases such as multiple sclerosis (MS), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and type 1 diabetes, suggesting an association between deficiency and increased risk or severity of these conditions. Some randomized controlled trials have shown modest benefits of vitamin D supplementation in reducing disease activity or relapse rates, particularly in MS and RA, though results are variable and sometimes inconsistent. Meta-analyses generally support a potential benefit, but emphasize the need for larger, well-designed trials.

While vitamin D3 is not a primary treatment for autoimmune diseases, its low risk and potential for benefit have led to recommendations for supplementation, especially in patients with documented deficiency. Current clinical guidelines often suggest maintaining adequate vitamin D levels as part of comprehensive autoimmune disease management.

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