Evidence supporting the use of: Vitamin D (cholecalciferol)
For the health condition: Autoimmune Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin D (cholecalciferol) has a scientific basis for its use in supporting or treating autoimmune disorders, though the strength of evidence varies depending on the specific condition and study design. Vitamin D is well-known for its role in calcium homeostasis and bone health, but it also exerts immunomodulatory effects. It influences both innate and adaptive immune responses, promoting regulatory T cells and reducing pro-inflammatory cytokine production. Epidemiological studies have shown that low serum levels of vitamin D are associated with a higher incidence of autoimmune diseases such as multiple sclerosis (MS), type 1 diabetes, rheumatoid arthritis, and systemic lupus erythematosus (SLE). Some randomized controlled trials and meta-analyses suggest that vitamin D supplementation may reduce disease activity, especially in MS and SLE, but results are inconsistent and often limited by small sample sizes and varying supplementation protocols.

Most guidelines recommend correcting vitamin D deficiency in people with autoimmune diseases, but there is insufficient evidence to support high-dose supplementation specifically as a treatment for these disorders. The majority of experts agree that maintaining sufficient vitamin D levels may be beneficial for immune regulation, yet more large, well-designed clinical trials are needed to determine optimal dosing and clear clinical benefits. Overall, while scientific rationale and some supporting data exist, the evidence is moderate and not definitive for therapeutic use in autoimmune disorders.

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