Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin C (ascorbic acid) has been studied for its role in immune function, but its use in autoimmune disorders is not robustly supported by high-quality clinical evidence. Vitamin C is an essential micronutrient with antioxidant properties and involvement in leukocyte (white blood cell) function, collagen synthesis, and control of inflammation. Historically, its supplementation has been associated with general immune system support, particularly in reducing the duration and severity of common colds. Some small studies and preclinical research suggest that vitamin C may modulate immune responses and exert anti-inflammatory effects, potentially benefitting autoimmune conditions such as rheumatoid arthritis or systemic lupus erythematosus. However, large-scale randomized controlled trials specifically assessing vitamin C’s efficacy in treating or modifying the course of autoimmune diseases are lacking.

Most recommendations for vitamin C supplementation in autoimmune disorders are based on its general immune-supporting and antioxidant properties rather than direct evidence of disease modification. Current guidelines do not endorse high-dose vitamin C as a primary or adjunctive therapy for autoimmune disorders. In summary, while there is a scientific rationale and some preliminary evidence for its supportive use, the quality and quantity of direct evidence remain limited, resulting in a low overall evidence rating for this indication.

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