Evidence supporting the use of: Quercetin
For the health condition: Autoimmune Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Quercetin, a flavonoid found in many fruits and vegetables, has garnered scientific interest for its potential immunomodulatory and anti-inflammatory effects relevant to autoimmune disorders. Preclinical studies (in vitro and animal models) have demonstrated that quercetin can modulate immune cell activity, suppress pro-inflammatory cytokines (such as TNF-α, IL-6, and IL-1β), and inhibit pathways like NF-κB, which are implicated in autoimmune pathogenesis. Some studies have also indicated that quercetin may help reduce oxidative stress, another factor involved in autoimmune tissue damage. However, direct clinical evidence in humans with autoimmune diseases (such as rheumatoid arthritis, lupus, or multiple sclerosis) is limited and largely preliminary. A few small pilot trials and case series suggest possible benefits in reducing inflammation or improving symptoms, but these studies are often underpowered or lack rigorous controls. The majority of data comes from animal models of autoimmune diseases, where quercetin supplementation has been shown to alleviate disease severity and immune dysregulation. Overall, while there is a plausible biological rationale and supportive preclinical evidence, robust clinical trials are lacking. Thus, the use of quercetin for autoimmune disorders is not yet validated by strong clinical science, but it is not solely based on tradition either. More large-scale, randomized controlled trials in humans are needed to establish efficacy and safety for this indication.

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