Green Lipped Mussel (Perna canaliculus), native to New Zealand, has been studied for its potential anti-inflammatory properties, particularly due to its unique combination of omega-3 fatty acids, glycosaminoglycans, and other bioactive components. Scientific interest in this shellfish supplement arose from anecdotal reports and traditional Maori usage, but contemporary research has focused on its effects in inflammatory conditions, including osteoarthritis and, to a lesser extent, autoimmune disorders such as rheumatoid arthritis (RA).

Clinical studies in humans have shown modest benefits for osteoarthritis symptoms, with some improvements in pain and mobility. For autoimmune disorders like RA, the evidence is less robust. A few small clinical trials and animal studies suggest that Green Lipped Mussel extracts may help reduce inflammation via modulation of cytokines and leukotrienes, but these effects are generally mild and not as well established as traditional disease-modifying treatments. Reviews and meta-analyses conclude that while there may be some anti-inflammatory action, the evidence is limited in scope, size, and quality, and more rigorous trials are needed.

In summary, there is some scientific rationale and limited clinical evidence supporting the use of New Zealand Green Lipped Mussel for autoimmune and inflammatory conditions, though the effects appear modest and are not universally accepted or recommended by medical guidelines. The evidence base currently warrants a low-to-moderate rating.