Evidence supporting the use of: L-glutamine
For the health condition: Autoimmune Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-glutamine is an amino acid that plays a critical role in immune function and intestinal health. Its use in autoimmune disorders is supported by some scientific rationale, particularly due to its ability to maintain gut barrier integrity and modulate immune responses. Several autoimmune diseases, such as inflammatory bowel disease (IBD, including Crohn’s disease and ulcerative colitis), are associated with increased intestinal permeability ("leaky gut"), and glutamine serves as a primary fuel source for enterocytes (intestinal cells), potentially helping to restore normal intestinal function.

Studies have shown that glutamine supplementation can reduce intestinal permeability and inflammation in animal models of autoimmune diseases. Some small human studies and clinical trials in patients with IBD and other gut-related autoimmune conditions have found modest benefits in reducing symptoms and supporting recovery, particularly in those with malnutrition or increased metabolic stress. However, results are mixed, and large-scale, high-quality clinical trials are limited.

While glutamine is not a frontline or standalone treatment for autoimmune disorders, it may have adjunctive benefits, especially for individuals with gut involvement or at risk of malnutrition. It is not generally recognized as effective for systemic autoimmune conditions without gastrointestinal involvement, such as lupus or rheumatoid arthritis. Overall, while there is some scientific support, the evidence is not strong, and more research is needed to make definitive recommendations.

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