Evidence supporting the use of: Bifidobacterium longum
For the health condition: Autoimmune Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bifidobacterium longum is a probiotic bacterium that has been studied for its role in modulating the immune system, making it of interest for autoimmune disorders. Scientific research, largely in animal models and some preliminary human studies, suggests that B. longum may help regulate immune responses by promoting anti-inflammatory cytokine production (such as IL-10) and reducing pro-inflammatory cytokines (such as TNF-alpha). This immunomodulatory effect is hypothesized to help restore immune balance, which is disrupted in autoimmune diseases. Some small clinical trials and pilot studies have explored its use in conditions like inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, and have found modest benefits in symptom management and gut barrier function. However, robust, large-scale clinical evidence in humans for a wide range of autoimmune disorders is still lacking. The mechanism appears to be related to changes in gut microbiota composition and the enhancement of regulatory T cell populations, which can dampen autoimmune activity. At this time, while there is a scientific rationale and some supportive evidence for B. longum in autoimmune conditions, the overall quality and quantity of evidence are limited, and its use should be considered adjunctive rather than primary therapy. More rigorous clinical research is needed to firmly establish its efficacy and safety for autoimmune disease management.

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