Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Astragaloside is a primary active component of Astragalus membranaceus, a herb widely used in Traditional Chinese Medicine (TCM). Astragalus and its extracts, including astragaloside, have a longstanding history of use for supporting immune health and addressing conditions thought to involve immune dysfunction, such as certain autoimmune disorders. The traditional rationale is that Astragalus "tonifies Qi" and helps restore balance to the body's systems, which has led to its inclusion in formulas intended to "strengthen the body's resistance" and support chronic illness recovery.

Modern scientific studies have investigated the immunomodulatory effects of Astragalus and astragalosides, generally finding that these compounds can influence cytokine production, enhance phagocytosis, or modulate immune cell activity in vitro and in animal models. However, high-quality clinical trials specifically assessing astragaloside's effectiveness for autoimmune disorders in humans are lacking. Some preliminary studies and reviews suggest potential benefits in conditions like systemic lupus erythematosus or rheumatoid arthritis, likely due to anti-inflammatory or immunoregulatory properties, but the evidence is limited and inconsistent.

In summary, the use of astragaloside for autoimmune disorders is primarily rooted in traditional practices, with some mechanistic support from laboratory studies but insufficient clinical validation. Thus, the evidence is rated as low (2/5), reflecting traditional use supplemented by limited experimental data rather than robust clinical evidence.

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