Evidence supporting the use of: DHA (Docosahexaenoic Acid)
For the health condition: Autism

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Synopsis

Source of validity: Scientific
Rating (out of 5): 1

DHA (Docosahexaenoic Acid), an omega-3 fatty acid, has been investigated for its potential role in supporting children with Autism Spectrum Disorder (ASD), primarily due to its importance in brain development and function. Several studies and small clinical trials have examined whether DHA supplementation could improve core symptoms of autism, such as social communication difficulties, repetitive behaviors, or cognitive deficits. However, the scientific evidence remains limited and inconsistent.

Some early observational studies noted that children with ASD may have lower levels of omega-3 fatty acids, including DHA, compared to neurotypical peers. This prompted hypotheses that supplementation might ameliorate symptoms. Randomized controlled trials (RCTs), however, have generally failed to demonstrate significant or clinically meaningful improvement in core ASD symptoms with DHA or mixed omega-3 supplementation. For example, a 2015 systematic review and meta-analysis (Bent et al., 2014; Mazahery et al., 2017) concluded that current evidence does not support routine use of omega-3 fatty acids, including DHA, for treating autism symptoms. Some studies report minor improvements in hyperactivity or irritability, but these findings are not consistent.

Overall, while there is a scientific rationale for testing DHA in autism, the clinical trial evidence supporting its efficacy is weak. Major guidelines do not recommend DHA supplementation as a primary treatment for ASD. Research continues, but at present, DHA’s use in autism is not scientifically validated beyond a very low level.

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