Synopsis

Source of validity: Scientific
Rating (out of 5): 1

Curcumin, the active polyphenolic compound in turmeric, has been investigated for its potential role in supporting individuals with Autism Spectrum Disorder (ASD) due to its anti-inflammatory and antioxidant properties. The rationale stems from emerging evidence that neuroinflammation and oxidative stress may play a role in the pathophysiology of autism. Preclinical studies, particularly animal models, have demonstrated that curcumin may attenuate behavioral abnormalities and reduce markers of neuroinflammation in rodents exhibiting autism-like symptoms. Limited small-scale human studies, such as pilot trials, have explored curcumin supplementation in children with ASD, sometimes in combination with other compounds (e.g., piperine to enhance absorption), and have reported mild improvements in some behavioral parameters. However, these studies often suffer from small sample sizes, short durations, and lack of rigorous controls. There is currently insufficient high-quality, large-scale clinical trial evidence to support curcumin as an established treatment for autism. Thus, while there is preliminary scientific interest and some early, low-quality evidence, the overall strength of evidence is weak and does not yet justify routine use. Further research, particularly well-designed human clinical trials, is needed to determine safety, efficacy, optimal dosing, and possible long-term effects of curcumin supplementation in ASD.

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Products containing curcumin

Nature's Sunshine Turmeric Curcumin (Formerly CurcuminBP)