Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Testosterone precursors, often referred to as prohormones, such as androstenedione or dehydroepiandrosterone (DHEA), have been used with the intent to enhance athletic performance and muscle growth by increasing endogenous testosterone levels. There is some scientific rationale for their use, as testosterone is known to play a significant role in muscle hypertrophy, strength gains, and recovery. However, clinical studies investigating the efficacy of these precursors in athletes and physically active individuals have produced inconsistent and generally modest results.

Research on androstenedione and DHEA supplementation in healthy adults shows minimal or no significant increase in testosterone levels, muscle mass, or strength compared to placebo. Some studies suggest possible increases in estrogen or androgenic side effects rather than clear anabolic benefits. The World Anti-Doping Agency (WADA) has banned many testosterone precursors due to their potential for misuse and the possibility of converting to active androgens in the body.

Overall, while there is a scientific basis for why testosterone precursors might be used as exercise aids, the clinical evidence supporting their effectiveness is weak (rated 2/5). Furthermore, concerns about safety and legality overshadow their limited potential benefits. They are not widely recommended by sports medicine or exercise science authorities for supporting athletic performance.

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