Synopsis

Source of validity: Scientific
Rating (out of 5): 3

L-alanyl-L-glutamine is a dipeptide composed of the amino acids L-alanine and L-glutamine. Its use as an athletic and exercise aid is primarily supported by scientific rationale and growing empirical evidence, rather than tradition. The main reason for its use in sports nutrition is to provide a stable, highly bioavailable form of glutamine, which plays a crucial role in muscle recovery, immune function, and gut health—areas often stressed during intense physical activity.

Glutamine is conditionally essential during periods of metabolic stress, such as intense exercise, where endogenous supply may not meet demand. Free glutamine, however, is unstable in solution and can degrade before absorption. L-alanyl-L-glutamine, being more stable, is efficiently absorbed by the gut via peptide transporters and rapidly hydrolyzed to release its amino acids.

Several studies have demonstrated that supplementation with L-alanyl-L-glutamine can enhance hydration status, reduce muscle soreness, and support immune function in athletes. For example, research published in Amino Acids and the Journal of the International Society of Sports Nutrition has shown improved fluid and electrolyte absorption and markers of reduced muscle damage post-exercise. However, while there is promising evidence, large-scale, long-term clinical trials are still somewhat limited, and the magnitude of benefit may be moderate rather than dramatic.

In summary, L-alanyl-L-glutamine is used as an exercise aid based on scientific mechanisms and preliminary clinical studies, but more robust research is needed for unequivocal recommendations.

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