Evidence supporting the use of: L-alanine
For the health condition: Athletic and Exercise Aids

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-alanine is a non-essential amino acid that plays a role in energy production and amino acid metabolism, which has attracted some interest in the context of athletic and exercise performance. The rationale for its use as an exercise aid is primarily based on its involvement in the glucose-alanine cycle. During prolonged or intense exercise, muscles break down amino acids for energy, producing alanine as a byproduct. Alanine is then transported to the liver, where it can be converted into glucose, helping to maintain blood sugar levels and potentially delaying fatigue.

Scientific studies specifically examining L-alanine supplementation for athletic performance are limited and less robust compared to other amino acids like beta-alanine. Most of the performance-related research focuses on beta-alanine, which is well-documented to enhance muscle carnosine levels and buffer lactic acid. In contrast, clinical trials directly testing L-alanine’s ergogenic (performance-enhancing) effects are sparse and generally show minimal to no benefit for strength, endurance, or recovery in healthy individuals.

While the biological plausibility exists due to its role in metabolism during exercise, current evidence from human studies does not strongly support the use of L-alanine as an effective exercise aid. Its use in this context is thus based more on theoretical considerations rather than solid clinical data. Therefore, the evidence rating is low, and athletes seeking performance benefits are more likely to benefit from other, better-studied amino acids or supplements.

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Other ingredients used for Athletic and Exercise Aids

7-Keto-DHEA
acetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha d-ribofuranose
alpha-ketoglutarate (AKG)
amino acids
ashwagandha
astaxanthin
bacillus subtilis
beet
beta-alanine
black tea
bovine
branched-chain amino acids
caffeine
capsaicinoids
coenzyme Q10 (CoQ10)
collagen
colostrum
conjugated linoleic acid (CLA)
cordyceps
creatine monohydrate
curcumin
eleuthero
ginseng
green tea
guarana
guayusa
l-isoleucine
l-alanine
l-alanyl-l-glutamine
l-arginine
l-carnitine
l-citrulline
l-glutamine
l-glycine
l-leucine
l-ornithine
l-taurine
l-tyrosine
l-valine
maca
magnesium
maltodextrin
muira puama
Acetyl-L-Tyrosine
omega-3 fatty acids
ornithine alpha-ketoglutarate
peppermint oil
protein
pyridoxal-5-phosphate (P-5-P)
rhodiola
black ginger
spirulina
tongkat ali
tribulus
vitamin C
watermelon
whey protein
suma
jiaogulan
capsicum
bee pollen
cistanche
electrolytes blend (proprietary)
yerba mate
algae
cocoa
brown rice protein
sea salt
1,3,7-Trimethylpurine-2,6-dione
2, 17a-dimethyl-17b-hydroxy-5a-androst-2-ene
Arginine Alpha Ketoglutarate
Antler
Arginine Creatine
Arginine nitrate
Arachidonic Acid
Arginine malate
Arginine aspartate
Alpha glyceryl
Alpha-ketoisocaproic acid
Agmatine
adenosine triphosphate (ATP)
Algal protein
Alpha hydroxyisocaproic acid
Arginine silicate
Bicarbonate
Beef Protein
Bovine Protein
Bulbine natalensis
Ba Ji Tian
BCAA
Camellia sinensis
Coconut
Casein
Cardarine
Capsinoids
Citrate malate
Capsiate
Creatine
D-Aspartic Acid
Dihydrocapsiate
Deer Velvet
D-Ribose
Ephedra
Elk antler
Ecdysteroids
Elthyl-Alpha-Guanido-Methyl-Ethanoate
Ecdysterone
Ephedrine
Isoleucine
Ketone Salts
Milk Protein
Quinoa Protein
salt
yohimbine

Other health conditions supported by l-alanine

Athletic and Exercise Aids