Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Isoleucine is one of the three branched-chain amino acids (BCAAs), along with leucine and valine, commonly used as dietary supplements among athletes and individuals engaged in intense physical activity. The rationale for using isoleucine, either alone or as part of BCAA mixtures, is based on its role in muscle metabolism, energy production, and recovery after exercise. Research indicates that BCAAs can help reduce exercise-induced muscle damage, perceived muscle soreness, and central fatigue, although much of this effect appears to be due primarily to leucine, with isoleucine and valine playing supporting roles. Some studies suggest that isoleucine may help increase glucose uptake into muscle cells and contribute to energy production during prolonged exercise, but the evidence is not robust or specific to isoleucine alone.

Overall, most of the scientific support comes from studies on BCAA mixtures, which show modest benefits for muscle recovery and reduced fatigue, but the effects are generally small and may not be clinically significant for all athletes. Evidence specifically supporting isoleucine as a standalone supplement for athletic performance or recovery is limited. Therefore, while there is a scientific rationale and some evidence supporting the use of BCAAs (including isoleucine) as exercise aids, the direct evidence for isoleucine alone remains weak, justifying a modest rating of 2 out of 5 for the strength of evidence.

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