Evidence supporting the use of: Ethyl-Alpha-Guanido-Methyl-Ethanoate
For the health condition: Athletic and Exercise Aids
Synopsis
Source of validity: Scientific
Rating (out of 5): 5
Ethyl-Alpha-Guanido-Methyl-Ethanoate is the IUPAC name for creatine ethyl ester, a derivative of creatine. Creatine, in various forms, is extensively researched and widely used as an ergogenic aid in athletic and exercise contexts. Numerous peer-reviewed studies have demonstrated that creatine supplementation enhances high-intensity exercise capacity and increases lean body mass during training. The mechanism involves increased phosphocreatine availability in muscle, which helps rapidly regenerate ATP, the primary energy carrier in cells, during short bursts of intense activity.
The traditional and most studied form is creatine monohydrate, but other forms like creatine ethyl ester have been marketed with claims of improved absorption. However, scientific evidence does not show that creatine ethyl ester has superior efficacy compared to creatine monohydrate; in fact, some studies suggest it may be less effective due to faster conversion to creatinine. Nevertheless, the underlying compound—creatine—has a robust scientific foundation supporting its use for improving strength, power output, and muscle mass in athletes.
Major sports and nutrition organizations, including the International Society of Sports Nutrition, recognize creatine as one of the most effective and safest supplements for athletic performance. Therefore, while creatine ethyl ester specifically is not superior, the use of creatine for athletic and exercise aid is strongly supported by scientific literature.
More about Ethyl-Alpha-Guanido-Methyl-Ethanoate
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7-Keto-DHEAAcetyl L-carnitine
adenosine 5-triphosphate disodium (ATP)
Alpha D-ribofuranose
alpha-ketoglutarate (AKG)
amino acids
ashwagandha
astaxanthin
bacillus subtilis
beet
beta-alanine
black tea
bovine
branched-chain amino acids
caffeine
capsaicinoids
coenzyme Q10 (CoQ10)
collagen
colostrum
conjugated linoleic acid (CLA)
cordyceps
creatine monohydrate
curcumin
eleuthero
ginseng
green tea
guarana
guayusa
l-isoleucine
L-alanine
L-alanyl-L-glutamine
L-arginine
l-carnitine
L-citrulline
L-glutamine
L-glycine
L-leucine
L-ornithine
L-taurine
l-tyrosine
L-valine
maca
magnesium
maltodextrin
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omega-3 fatty acids
ornithine alpha-ketoglutarate
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protein
pyridoxal-5-phosphate (P-5-P)
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spirulina
Tongkat ali
tribulus
vitamin C
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Whey protein
suma
jiaogulan
capsicum
bee pollen
cistanche
electrolytes blend (proprietary)
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cocoa
brown rice protein
sea salt
1,3,7-Trimethylpurine-2,6-dione
arginine alpha ketoglutarate
antler
arginine creatine
Arginine nitrate
arachidonic acid
Arginine malate
Arginine aspartate
Alpha glyceryl
Alpha-ketoisocaproic acid
Agmatine
Adenosine triphosphate (ATP)
Algal protein
Alpha hydroxyisocaproic acid
Arginine silicate
bicarbonate
Beef Protein
bovine protein
Bulbine natalensis
ba ji tian
BCAA
Camellia sinensis
coconut
casein
cardarine
capsinoids
citrate malate
capsiate
creatine
D-Aspartic Acid
dihydrocapsiate
deer velvet
D-Ribose
Ephedra
eurycomanone
elk antler
Eurycoma Longifolia
ecdysteroids
Ethyl-Alpha-Guanido-Methyl-Ethanoate
ecdysterone
ephedrine
Fadogia agrestis
guanidinoacetic acid
Ginsenosides
Glutamine
GMS-ribose
glucose
Glycocyamine
Guaranine
Glycerol
Higenamine
hydroxymethylbutyrate
HMB hydroxymethylbutyrate
horny goat weed
isomaltulose
Isoleucine
kola nut
ketone salts
lactalbumin
Laxogenin
macamides
maral root
Mineral ascorbate
Milk Protein
Methylxanthine
Methylliberine
Mate
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macaenes
Nitrous Malate (TM) Diarginine Malate
Ornithine
Phosphocreatine
pyrroloquinoline quinone
paraxanthine
Phytoecdysteroid
pyruvate
Phosphatidic Acid
Piper nigrum
Palatinose
Peptides
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Rhaponticum
ribose
robusta coffee
Synephrine
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salt
Sida cordifolia
Theobromine
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Turkesterone
Trichopus zeylanicus
Theacrine
Teacrine
Tribulus Terrestris
Valine alpha-hydroxyisocaproate
Xanthine
Yohimbine
Other health conditions supported by Ethyl-Alpha-Guanido-Methyl-Ethanoate
Athletic and Exercise AidsBody Building
Endurance (lack of)
Energy (lack of)
Exercise
Fatigue