Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Ecdysterone, a naturally occurring ecdysteroid found in plants like spinach and in some insects, has gained attention as a potential performance-enhancing supplement for athletes. Its use is primarily justified by emerging scientific evidence, rather than longstanding traditional use in this context. Several recent studies have indicated that ecdysterone supplementation may have anabolic effects, promoting increases in muscle mass and strength. For example, a notable 2019 randomized controlled trial published in Archives of Toxicology found that resistance-trained men who consumed ecdysterone for ten weeks gained significantly more muscle mass and strength than those taking a placebo. The proposed mechanism involves the activation of the estrogen receptor beta, which may stimulate protein synthesis without the androgenic side effects associated with anabolic steroids.

However, while these findings are promising, the overall body of research is still limited, with relatively few human trials and some inconsistencies in dosages and study designs. Additionally, the long-term safety profile of ecdysterone supplementation has not been fully established. Despite its inclusion on the World Anti-Doping Agency’s (WADA) monitoring list, it is not currently banned, but ongoing research could influence its regulatory status. In summary, ecdysterone is supported by a growing but still moderate level of scientific evidence (rated 3 out of 5) for its use as an exercise and athletic aid, but further large-scale, long-term studies are required to confirm its efficacy and safety.

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