Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Creatine gluconate is a form of creatine in which creatine is bound to a gluconic acid moiety. Creatine itself is one of the most extensively studied supplements in the context of athletic performance and exercise aids, with strong scientific validation for its ability to increase strength, power output, and muscle mass, particularly during high-intensity, short-duration exercise. The bulk of evidence supporting creatine's efficacy is based on creatine monohydrate, the most common and well-researched form. The rationale for using creatine gluconate, as with other alternative creatine salts, is the potential for improved solubility, absorption, or gastrointestinal tolerance, but direct comparative studies are limited.

While there is robust evidence for creatine supplementation in general, specific evidence for creatine gluconate is sparse. There are few, if any, peer-reviewed studies directly evaluating the efficacy or safety of creatine gluconate compared to creatine monohydrate or placebo. Thus, its use in athletic and exercise aids is justified by extrapolation from the extensive body of research on creatine as a whole, rather than from specific studies on the gluconate form. Given this, the evidence rating is moderate (3/5): strong for creatine overall, but limited for this specific salt. Until more research is conducted on creatine gluconate itself, its use relies on the general validation of creatine as an athletic aid.

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